Lead Drug Discovery Scientist

DeepLife is hiring!

About

DeepLife is a pre-series A startup focused on addressing the urgent need to increase drug discovery reliability by acting on the earliest step, drug target identification. This consists of identifying, a molecular target, such as a protein, that will trigger the transition from disease to healthy cells. With current methods, only 1 target in 10,000 reach the market, leading to a significant loss of time and efforts in the community.

Our approach is to leverage the recent revolution in the omics data, measuring precisely cells activity at large scale, and build foundation models to mimic cell behavior in various contexts and identify the optimal trigger to reverse disease state.

Half of the team today is dedicated to build the largest omics database, aka omics atlas, to map all human body tissues and diseases and reduce experimental biases.

We offer a research friendly environment, with 90% of the company holding a PhD, with academic collaborations and publications. The team is international and composed of +10 different nationalities. The company is remote first with most of the work is remote and regular events organized in our offices in Paris.

Job Description

Overview:

We are seeking a Lead Drug Discovery Scientist with a proven track record in advancing drugs through clinical phases who will be in charge of delivering the best repurposed drugs to our partners. The candidate will be a central element in our drug discovery strategy, bridging the needs in drug discovery with the development of our digital twin of the cell developed in R&D. This role requires a strong expertise in deep learning—preferably in foundation models—systems biology, and computational biology, especially in single-cell analysis.

Key Responsibilities:

Repurposed Drug Delivery: Lead the identification, validation, and delivery of the best repurposed drugs to our partners, ensuring they are based on robust scientific evidence and align with partners’ needs.

Drug Candidate Validation: Evaluate and validate drug candidates predicted by our computational models, ensuring they are of high quality and suitable for progression into clinical development and commercialization.

Bridge R&D and Drug Discovery Needs: Act as a key liaison between the R&D team and drug discovery efforts, ensuring that the development of our digital twin of the cell aligns with practical drug development needs.

Deep Learning Application: Utilize extensive experience in deep learning, preferably with foundation models, to enhance drug discovery processes and improve model predictions.

Systems Biology and Single-Cell Analysis: Apply expertise in systems biology and single-cell analysis to interpret model outputs and understand the mechanisms of action of potential drug candidates.

Client Engagement and Partnership Development: Collaborate closely with partners, presenting repurposed drugs and demonstrating the value of our models to pharmaceutical and biotech companies.

Strategic Feedback to R&D: Provide informed feedback to the R&D team based on drug discovery needs and drug candidate development to guide the enhancement of our digital twin model.

Leadership and Mentorship: Mentor junior scientists and contribute to team development and growth, fostering a culture of innovation and excellence.

Interdisciplinary Collaboration: Work with biologists, chemists, clinicians, data scientists, and other stakeholders to translate computational predictions into actionable drug development strategies.

Communication: Present complex scientific data and concepts clearly and persuasively to clients, partners, stakeholders, and team members, fostering strong relationships and facilitating successful collaborations.

Continuous Learning and Innovation: Stay abreast of the latest developments in drug discovery, computational biology, deep learning, systems biology, and single-cell analysis to maintain cutting-edge expertise.

Preferred Experience

Qualifications (Ranked from Most Important to Least Important):

1. Ph.D. in Computational Biology, Bioinformatics, Systems Biology, Molecular Biology, Pharmacology, or a related field.

2. Proven track record of successful drug discovery, with experience advancing drugs through clinical phases.

3. Expertise in delivering repurposed drugs, including the ability to translate computational findings into actionable drug candidates for partners.

4. Strong background in deep learning, preferably with experience in foundation models applied to drug discovery.

5. Extensive experience in systems biology and single-cell analysis, utilizing these skills to understand drug mechanisms of action.

6. Ability to bridge R&D and drug discovery, ensuring alignment between computational model development and practical drug development needs.

7. Experience in client-facing roles, delivering repurposed drug candidates, and effectively communicating complex scientific concepts to non-expert audiences.

8. Leadership and mentorship abilities, with experience managing and developing scientific teams.

9. Strategic thinker with the ability to provide feedback to R&D teams, influencing the development of computational models and drug discovery strategies.

10. Experience working in interdisciplinary teams, fostering collaboration across various scientific domains.

11. Proficiency in programming languages such as Python or R, and familiarity with bioinformatics tools and libraries.

12. Strong communication skills, with the ability to present complex information clearly to diverse audiences.

13. Continuous learner, keeping up-to-date with advancements in computational biology, deep learning, and drug discovery methodologies.

Additional Information

  • Contract Type: Full-Time
  • Location: Paris
  • Possible full remote